- Title
- Effect of low-volume combined aerobic and resistance high-intensity interval training on vascular health in people with type 2 diabetes: a randomised controlled trial
- Creator
- Cox, Emily R.; Gajanand, Trishan; Coombes, Jeff S.; Bailey, Tom G.; Keating, Shelley E.; Hordern, Matthew D.; Burton, Nicola W.; Green, Daniel J.; Ramos, Joyce S.; Ramos, Maximiano V.; Fassett, Robert G.; Cox, Stephen V.
- Relation
- European Journal of Applied Physiology Vol. 124, p. 2819-2833
- Publisher Link
- http://dx.doi.org/10.1007/s00421-024-05473-8
- Publisher
- Springer
- Resource Type
- journal article
- Date
- 2024
- Description
- Purpose: We compared the effects of low-volume combined aerobic and resistance high-intensity interval training (C-HIIT), combined moderate-intensity continuous training (C-MICT) and waitlist control (CON) on vascular health after 8-weeks of supervised training, and an additional 10-months of self-directed training, in adults with type 2 diabetes (T2D). Methods: Sixty-nine low active adults with T2D were randomised to 8-weeks of supervised C-HIIT (3 times/week, 78-min/week), C-MICT (current exercise guidelines, 4 times/week, 210-min/week) or CON. CON underwent usual care for 8-weeks before being re-randomised to C-HIIT or C-MICT. This was followed by 10-months of self-directed training for participants in C-HIIT and C-MICT. Vascular outcomes were evaluated at baseline, 8-weeks, and 12-months. Results: After 8-weeks, supervised C-HIIT significantly improved relative flow-mediated dilation (FMD) compared with CON (mean difference [MD] 0.8% [0.1, 1.4], p = 0.025). Although not significantly different from CON, the magnitude of change in relative FMD following 8-weeks of supervised C-MICT was similar (MD 0.8% [–0.1, 1.7], p = 0.080). There were no differences in haemodynamic indices, carotid-femoral pulse wave velocity (cfPWV), or aortic reservoir pressure between groups at 8-weeks. After 12-months, there was a significant reduction in haemodynamic indices (time effect, p < 0.05) for both C-HIIT and C-MICT, with no between-group difference. The reduction in cfPWV over 12-months was significantly greater in C-MICT than C-HIIT (group × time effect, p = 0.018). There was no difference in FMD over time or between groups at 12-months. Conclusions: Short-term supervised C-HIIT and C-MICT both increased brachial artery FMD compared with CON. Long-term C-HIIT and C-MICT were beneficial for improving haemodynamic indices, but not brachial artery FMD. C-MICT was superior to C-HIIT for improving cfPWV at 12-months. Trial Registration: Australian New Zealand Clinical Trials Registry Identifier ACTRN12615000475549.
- Subject
- blood pressure; diabetes mellitus; type 2; exercise; flow-mediated dilation; high-intensity interval training; SDG 3; SDG 7; Sustainable Development Goal
- Identifier
- http://hdl.handle.net/1959.13/1510320
- Identifier
- uon:56380
- Identifier
- ISSN:1439-6319
- Rights
- x
- Language
- eng
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